PROPIONATE 250mg/ml

Males:Testosterone Propionate is indicated for replacement therapy in conditions associated with a deficiency or absence of  endogenous testosterone; A.Primary hypogonadism(congenital or acquired)–testicular failure due to cryptorchidism, bilateral torsion, orchitis, vanishing testis syndrome, or orchidectomy B.Hypogonadotropichypogonadism (congenital or acquired) —idiopathic gonadotropin or LHRH deficiency or pituitary-hypothalamic injury from tumours, trauma, or radiation Female:Testosterone Propionate may be used secondarily in women with advancing in operable metastatic (skeletal) mammary cancer who are 1 to 5 years postmenopausal.Testosterone Propionate has been used for the management of postpartum breast pain and engorgement.

Drug interactions:

1.Oxyphenbutazone-Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone.

2.Insulin-In diabetic patients, the metabolic effects of androgens may decrease blood glucose and insulin requirements.

Overdosage:

There have been no reports of acute overdosage with the anabolics.

Precautions:

General: Patients with benign prostatic hypertrophy maydevelop acute urethral obstruction. Priapism or excessive sexual stimulation may develop.

Oligospermia may occur after prolonged administration or excessive dosage.If any of these effects appears, the androgen should be stopped and if restarted, a lower dosage should be utilized. Testosterone Propionate should not be used interchangeably with testosterone cypionate because of differences in duration of action.

Dosage and adminstration:

Testosterone Propionate is administered by intramuscular injection. It must not be given intravenously. Intramuscular injections should be given deep in the gluteal muscle. The suggested dosage varies. Depending on the age, sex, and diagnosis of the individual patient Replacement therapy in androgen deficient males should be in the range of 25 -50mg 2 or 3 times a week.

Side effects:

There are rare reports of hepatocellular carcinoma in patients receiving long term therapy with androgens in high doses.

Withdrawal of the drugs did not lead to regression of the tumours in all cases.

Warnings:

In patients with breast cancer, androgen therapy may cause hypercalcemia by stimulating osteolysis, In this case, the drug should be discontinued.

Prolonged use of high doses of androgens has been associated with the development of peliosishepatic and hepatic neoplasms, including hepatocellular carcinoma hepatic can be a life-threatening or fatal complication. Geriatric patients treated with androgens may be at an increased risk for the development of prostatic hypertrophy and prostatic carcinoma.

Supplied / storage:

Testosterone Propionate is supplied in 5 x1ml ampules. Ampules should be stored at controlled room temperatures below 30˚C and protected from light.Parenteral drug products should be inspected visually for particulate matter and discolouration prior to administration, whenever solution and container permit.Warming and shaking the ampules should redissolve any crystals that may have formed during storage at temperature lower than recommended.

If it has expired or is damaged, retum to your pharmacist.

Keep out of the reach and sight of children.